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Ensartinib hydrochloride
CAS No. 2137030-98-7
Ensartinib hydrochloride ( Ensartinib dihydrochloride; X-396 dihydrochloride )
产品货号. M27551 CAS No. 2137030-98-7
Ensartinib dihydrochloride is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK mutations.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥689 | 有现货 |
|
| 5MG | ￥1191 | 有现货 |
|
| 10MG | ￥1936 | 有现货 |
|
| 25MG | ￥3953 | 有现货 |
|
| 50MG | ￥5767 | 有现货 |
|
| 100MG | ￥7995 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称Ensartinib hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Ensartinib dihydrochloride is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK mutations.
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产品描述Ensartinib dihydrochloride is a potent new-generation ALK inhibitor with high activity against CNS metastases and a broad range of known crizotinib-resistant ALK mutations. It potently inhibits both wild-type ALK and ALK variants (C1156Y, F1174, G1202R, L1196M, S1206R, and T1151 mutants) with in vitro IC50s of <4 nM.(In Vitro):Ensartinib potently inhibits both wild-type ALK and all evaluated ALK variants (C1156Y, F1174, G1202R, L1196M, S1206R, and T1151 mutants) with in vitro IC50s of <4 nM. Besides ALK, ensartinib also potently inhibits GOPC-ROS1, TPM3-TRKA, and TRKC with an IC50 of <1 nM, and inhibits EphA1, EphA2, EphB1 and c-MET with an IC50 of 1-10 nM.
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同义词Ensartinib dihydrochloride; X-396 dihydrochloride
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通路Others
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靶点Other Targets
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受体mitochondrial cytochrome bc1
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研究领域——
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适应症——
化学信息
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CAS Number2137030-98-7
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分子量634.4
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分子式C26H29Cl4FN6O3
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纯度>98% (HPLC)
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溶解度——
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SMILESCl.Cl.CC(Oc1cc(nnc1N)C(=O)Nc1ccc(cc1)C(=O)N1CC(C)NC(C)C1)c1c(Cl)ccc(F)c1Cl
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Benjamin M Vincent, et al. A Fungal-Selective Cytochrome Bc 1 Inhibitor Impairs Virulence and Prevents the Evolution of Drug Resistance.Cell Chem Biol. 2016 Aug 18;23(8):978-991.
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